Nanotechnology and nanomaterials solutions for COVID-19: Diagnostic testing, antiviral and antimicrobial coatings and surfaces, air-borne filtration, facemasks, PPE, drug delivery and therapeutics

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Applications, markets, companies and COVID-19 adjusted market revenues

Published May 5 2020, 325 pages, 37 tables, 52 figures

Nanotechnology and nanomaterials can significantly address the many clinical and public healthcare challenges that have arisen from the coronavirus pandemic. This analysis examines in detail how nanotechnology and nanomaterials can help in the fight against this pandemic disease, and ongoing mitigation strategies. Nano-based products are currently being developed and deployed for the containment, diagnosis, and treatment of Covid-19.

Nanotechnology and nanomaterials promise:

  • Improved and virus disabling air filtration.
  • Low-cost, scalable detection methods for the detection of viral particles
  • Enhanced personal protection equipment (PPE) including facemasks.
  • New antiviral vaccine and drug delivery platforms.
  • New therapeutic solutions.

 

Report contents include:

  • Market analysis of nano-based diagnostic tests for COVID-19 including nanosensors incorporating gold nanoparticles, iron oxide nanoparticles, graphene, quantum dots, carbon quantum dots and carbon nanotubes. Market revenues adjusted to pandemic outcomes. in-depth company profiles. 
  • Market analysis of antiviral and antimicrobial nanocoatings for COVID-19 mitigation. Market revenues adjusted to pandemic outcomes. In-depth company profiles. 
  • Market analysis of air-borne virus filtration including photocatalytic Nano-TiO2 filters, nanofiber filers, nanosilver, nanocellulose, graphene and carbon nanotube filtration. Market revenues adjusted to pandemic outcomes. In-depth company profiles. 
  • Market analysis of antiviral and antimicrobial nanocoatings for surfaces including fabric (mask, gloves, doctor coats, curtains, bed sheet), metal (lifts, doors handle, nobs, railings, public transport), wood (furniture, floors and partition panels), concrete (hospitals, clinics and isolation wards) and plastics (switches, kitchen and home appliances).
  • Market analysis of nano-based facemask and other PPE products. Market revenues adjusted to pandemic outcomes. In-depth company profiles. 
  • Nanotherapies and drug delivery vehicles currently being produced and clinical trials of vaccines for COVID-19. Market revenues adjusted to pandemic outcomes. In-depth company profiles. 
  • Key scientific breakthroughs and developments that are underway right now.

 

 

Download Table of contents (PDF)

1    EXECUTIVE SUMMARY................................................................... 22

 

2    RESEARCH SCOPE AND METHODOLOGY................................... 23

  • 2.1    Report scope................................................................................................................... 23
  • 2.2    Research methodology..................................................................................................24

 

3    INTRODUCTION............................................................................. 26

 

4    DIAGNOSTIC TESTING.................................................................... 28

  • 4.1    Nanotechnology and nanomaterials solutions..............................................................29
    • 4.1.1      Current Diagnostic Tests for COVID-19...........................................................29
    • 4.1.2      Emerging Diagnostic Tests for COVID-19....................................................... 30
  • 4.2    Nanosensors.................................................................................................................. 32
    • 4.2.1      Gold nanoparticles............................................................................................32
    • 4.2.2      Iron oxide nanoparticles................................................................................... 37
    • 4.2.3      Graphene biosensors......................................................................................... 38
    • 4.2.4      Quantum dot barcoding.....................................................................................41
    • 4.2.5      Carbon quantum dots.......................................................................................... 42
    • 4.2.6      Carbon nanotubes................................................................................................. 42
  • 4.3    Market revenues..................................................................................................................44
    • 4.3.1      Market estimates adjusted to pandemic demand, forecast to 2030..................... 44
  • 4.4    Companies...........................................................................46 (32 COMPANY PROFILES)
  • 4.5    Academic research............................................................................................................... 67

 

5    ANTIVIRAL AND ANTIMICROBIAL COATINGS AND SURFACES 69

  • 5.1    Nanotechnology and nanomaterials solutions....................................................................69
    • 5.1.1      Nanocoatings........................................................................................................... 72
    • 5.1.2      Applications............................................................................................................76
    • 5.1.3      Anti-viral nanoparticles and nanocoatings............................................................. 78
      • 5.1.3.1        Reusable Personal Protective Equipment (PPE)....................................... 80
      • 5.1.3.2        Wipe on coatings........................................................................................80
    • 5.1.4      Graphene-based coatings..........................................................................................83
      • 5.1.4.1        Properties....................................................................................................83
      • 5.1.4.2        Graphene oxide...........................................................................................85
      • 5.1.4.3        Reduced graphene oxide (rGO).................................................................. 85
      • 5.1.4.4        Markets and applications............................................................................ 87
    • 5.1.5      Silicon dioxide/silica nanoparticles (Nano-SiO2) -based coatings..........................87
      • 5.1.5.1        Properties....................................................................................................87
      • 5.1.5.2        Antimicrobial and antiviral activity.............................................................88
      • 5.1.5.3        Easy-clean and dirt repellent....................................................................... 90
    • 5.1.6      Nanosilver-based coatings.......................................................................................... 90
      • 5.1.6.1        Properties.......................................................................................................90
      • 5.1.6.2        Antimicrobial and antiviral activity................................................................91
      • 5.1.6.3        Markets and applications............................................................................... 92
      • 5.1.6.4        Commercial activity.........................................................................................93
    • 5.1.7      Titanium dioxide nanoparticle based coatings.............................................................. 94
      • 5.1.7.1        Properties.........................................................................................................94
      • 5.1.7.2        Exterior and construction glass coatings......................................................... 96
      • 5.1.7.3        Outdoor air pollution........................................................................................97
      • 5.1.7.4        Interior coatings................................................................................................98
      • 5.1.7.5        Medical facilities.................................................................................................99
      • 5.1.7.6        Wastewater Treatment.......................................................................................99
      • 5.1.7.7        Antimicrobial coating indoor light activation....................................................99
    • 5.1.8      Zinc oxide nanoparticle-based coatings........................................................................... 100
      • 5.1.8.1        Properties..............................................................................................................100
      • 5.1.8.2        Antimicrobial activity...........................................................................................101
    • 5.1.9      Nanocellullose (cellulose nanofibers and cellulose nanocrystals)-based coatings............... 103
      • 5.1.9.1        Properties...............................................................................................................103
      • 5.1.9.2        Antimicrobial activity............................................................................................104
    • 5.1.10    Carbon nanotube-based coatings.....................................................................................105
      • 5.1.10.1      Properties...........................................................................................................105
      • 5.1.10.2      Antimicrobial activity........................................................................................ 105
    • 5.1.11    Fullerene-based coatings................................................................................................... 106
      • 5.1.11.1      Properties................................................................................................................106
      • 5.1.11.2      Antimicrobial activity..............................................................................................107
    • 5.1.12    Chitosan nanoparticle-based coatings................................................................................108
      • 5.1.12.1      Properties............................................................................................................... 108
      • 5.1.12.2      Wound dressings..................................................................................................... 110
      • 5.1.12.3      Packaging coatings and films................................................................................... 110
      • 5.1.12.4      Food storage.............................................................................................................110
    • 5.1.13    Copper nanoparticle-based coatings..................................................................................111
      • 5.1.13.1      Properties................................................................................................................. 111
      • 5.1.13.2      Application in antimicrobial nanocoatings.............................................................. 111
  • 5.2    Market revenues...........................................................................................................................112
    • 5.2.1      Market revenues adjusted to pandemic demand, forecast to 2030.....................................112
  • 5.3    Companies.................................................................................. 117 (113 COMPANY PROFILES)
  • 5.4    Academic research........................................................................................................ 201

 

6    AIR-BORNE VIRUS FILTRATION.................................................. 203

  • 6.1    Nanotechnology and nanomaterials solutions............................................................... 203
    • 6.1.1      Photocatalytic nano-titanium dioxide...............................................................203
    • 6.1.2      Nanofibers........................................................................................................... 205
    • 6.1.3      Nanosilver............................................................................................................206
    • 6.1.4      Nanocellulose.......................................................................................................207
      • 6.1.4.1        Cellulose nanofibers................................................................................ 207
      • 6.1.4.2        Bacterial nanocellulose...........................................................................209
    • 6.1.5      Graphene................................................................................................................. 209
    • 6.1.6      Carbon nanotubes................................................................................................... 211
  • 6.2    Market revenues....................................................................................................................213
    • 6.2.1      Market estimates adjusted to pandemic demand, forecast to 2030...................... 213
  • 6.3    Companies..............................................................................214 (34 COMPANY PROFILES)
  • 6.4    Academic research....................................................................................................... 247

 

7    FACEMASKS AND OTHER PPE.................................................... 248

  • 7.1    Nanotechnology and nanomaterials solutions......................................................... 248
    • 7.1.1      Nanofibers....................................................................................................249
    • 7.1.2      Nanocellulose...............................................................................................249
    • 7.1.3      Nanosilver.....................................................................................................250
    • 7.1.4      Graphene....................................................................................................... 252
    • 7.1.5      Facemasks......................................................................................................253
    • 7.1.6      Protective textiles.......................................................................................... 255
  • 7.2    Market revenues..........................................................................................................258
    • 7.2.1      Market estimates adjusted to pandemic demand, forecast to 2030............. 258
  • 7.3    Companies...........................................................................259 (22 COMPANY PROFILES)
  • 7.4    Academic research................................................................................................264

 

8    DRUG DELIVERY AND THERAPEUTICS...................................... 266

  • 8.1    Nanotechnology and nanomaterials solutions............................................................ 266
    • 8.1.1      Products........................................................................................................268
    • 8.1.2      Nanocarriers................................................................................................... 272
    • 8.1.3      Virus-like particles (VLPs)..............................................................................274
    • 8.1.4      Polymer nanoparticles...................................................................................275
      • 8.1.4.1        Chitosan nanoparticles......................................................................275
    • 8.1.5      Liposomes........................................................................................................ 276
      • 8.1.5.1        Lipid nanoparticles in RNA-based vaccines...................................... 276
    • 8.1.6      Inorganic nanoparticles..................................................................................277
    • 8.1.6.1        Iron oxide nanoparticles........................................................................... 277
    • 8.1.6.2        Quantum dots............................................................................................278
    • 8.1.6.3        Silver nanoparticles.................................................................................279
    • 8.1.6.4        Gold nanoparticles...................................................................................280
  • 8.2    Market revenues..........................................................................................................282
    • 8.2.1      Market estimates adjusted to pandemic demand, forecast to 2025.............282
  • 8.3    Companies.....................................................................283 (60 COMPANY PROFILES)
  • 8.4    Academic research............................................................................................... 313

 

9    OTHER TECHNOLOGIES............................................................... 314

  • 9.1    Disinfection chambers............................................................................................... 314
  • 9.2    Smart windows.........................................................................................................314

 

10 REFERENCES................................................................................ 314

 

Tables

  • Table 1. Current Diagnostic Tests for COVID-19............................................................................................ 28
  • Table 2. Development phases of diagnostic tests.......................................................................................... 30
  • Table 3. Emerging Diagnostic Tests for COVID-19........................................................................................ 30
  • Table 4. Gold nanoparticle reagent suppliers list............................................................................................ 33
  • Table 5. Global revenues for nanotech-based diagnostics and testing, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates.............................................................................. 44
  • Table 6. Academic research in nano-based COVID-19 diagnostics and testing........................................... 67
  • Table 7: Anti-microbial and antiviral nanocoatings-Nanomaterials used, principles, properties and applications................................................................................................................................................................... 70
  • Table 8. Nanomaterials utilized in antimicrobial and antiviral nanocoatings coatings-benefits and applications.................................................................................................................................................................... 72
  • Table 9: Properties of nanocoatings................................................................................................................ 75
  • Table 10: Antimicrobial and antiviral nanocoatings markets and applications............................................... 77
  • Table 11: Nanomaterials used in nanocoatings and applications.................................................................. 81
  • Table 12: Graphene properties relevant to application in coatings................................................................ 84
  • Table 13. Bactericidal characters of graphene-based materials.................................................................... 86
  • Table 14. Markets and applications for antimicrobial and antiviral nanocoatings graphene nanocoatings... 87
  • Table 15. Markets and applications for antimicrobial and antiviral nanosilver coatings................................. 92
  • Table 16. Commercial activity in antimicrobial nanosilver nanocoatings....................................................... 93
  • Table 17. Antibacterial effects of ZnO NPs in different bacterial species..................................................... 102
  • Table 18. Types of carbon-based nanoparticles as antimicrobial agent, their mechanisms of action and characteristics......................................................................................................................................... 107
  • Table 19. Mechanism of chitosan antimicrobial action................................................................................. 109
  • Table 20. Global revenues for antimicrobial and antiviral nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................................ 112
  • Table 21. Global revenues for Anti-fouling & easy clean nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................................ 113
  • Table 22. Global revenues for self-cleaning (bionic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates................................................................................. 114
  • Table 23. Global revenues for self-cleaning (photocatalytic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 115
  • Table 24. Antimicrobial, antiviral and antifungal nanocoatings research in academia................................. 201
  • Table 25. CNF membranes........................................................................................................................... 207
  • Table 26. Global revenues for nanotech-based air-borne virus filtration, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 213
  • Table 27: Oji Holdings CNF products............................................................................................................ 239
  • Table 28. Academic research in nano-based air-borne virus filtration......................................................... 247
  • Table 29. Companies producing nanomaterial facemasks........................................................................... 254
  • Table 30. Applications in textiles, by nanomaterials type and benefits thereof............................................ 255
  • Table 31. Global revenues for nanotech-based facemasks and PPE, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................................ 258
  • Table 32. Academic research in nano-based facemasks and other PPE.................................................... 264
  • Table 33. Applications in drug formulation and delivery, by nanomaterials type and benefits thereof........ 266
  • Table 34. Nanotechnology drug products..................................................................................................... 269
  • Table 35. List of antigens delivered by using different nanocarriers for the treatment of different diseases. 274
  • Table 36. Global revenues for nano-based drug delivery and therapeutics, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 282
  • Table 37. Academic research in nano-based drug delivery and therapeutics to address COVD-19........... 313

 

Figures

  • Figure 1. Anatomy of COVID-19 Virus............................................................................................................ 26
  • Figure 2. Schematic of COVID-19 FET sensor incorporating graphene........................................................ 39
  • Figure 3. Graphene-based sensors for health monitoring.............................................................................. 40
  • Figure 4. Global revenues for nanotech-based diagnostics and testing, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates.............................................................................. 45
  • Figure 5. Schematic of anti-viral coating using nano-actives for inactivation of any adhered virus on the surfaces..................................................................................................................................................... 79
  • Figure 6: Graphair membrane coating............................................................................................................ 83
  • Figure 7: Antimicrobial activity of Graphene oxide (GO)................................................................................ 85
  • Figure 8. Nano-coated self-cleaning touchscreen.......................................................................................... 89
  • Figure 9: Hydrophobic easy-to-clean coating.................................................................................................. 90
  • Figure 10 Anti-bacterial mechanism of silver nanoparticle coating................................................................ 91
  • Figure 11: Mechanism of photocatalysis on a surface treated with TiO2 nanoparticles................................ 95
  • Figure 12:  Schematic showing the self-cleaning phenomena on superhydrophilic surface.......................... 95
  • Figure 13: Titanium dioxide-coated glass (left) and ordinary glass (right)...................................................... 97
  • Figure 14:  Self-Cleaning mechanism utilizing photooxidation....................................................................... 97
  • Figure 15: Schematic of photocatalytic air purifying pavement...................................................................... 98
  • Figure 16: Schematic of photocatalytic water purification............................................................................... 99
  • Figure 17. Schematic of antibacterial activity of ZnO NPs............................................................................ 102
  • Figure 18: Types of nanocellulose................................................................................................................ 104
  • Figure 19. Mechanism of antimicrobial activity of carbon nanotubes........................................................... 106
  • Figure 20: Fullerene schematic..................................................................................................................... 107
  • Figure 21. TEM images of Burkholderia seminalis treated with (a, c) buffer (control) and (b, d) 2.0 mg/mL chitosan; (A: additional layer; B: membrane damage)........................................................................... 109
  • Figure 22. Global revenues for antimicrobial and antiviral nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 113
  • Figure 23. Global revenues for anti-fouling and easy-to-clean nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 114
  • Figure 24. Global revenues for self-cleaning (bionic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates................................................................................. 115
  • Figure 25. Global revenues for self-cleaning (photocatalytic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 116
  • Figure 26. Lab tests on DSP coatings........................................................................................................... 137
  • Figure 27. GrapheneCA anti-bacterial and anti-viral coating........................................................................ 144
  • Figure 28. Microlyte® Matrix bandage for surgical wounds.......................................................................... 151
  • Figure 29. Self-cleaning nanocoating applied to face masks....................................................................... 154
  • Figure 30. NanoSeptic surfaces.................................................................................................................... 172
  • Figure 31. NascNanoTechnology personnel shown applying MEDICOAT to airport luggage carts............ 177
  • Figure 32: Schematic of photocatalytic indoor air purification filter.............................................................. 204
  • Figure 33. Filter paper based on algae nanocellulose.................................................................................. 209
  • Figure 34. Multi-layered cross section of CNF-nw........................................................................................ 215
  • Figure 35: Asahi Kasei CNF fabric sheet...................................................................................................... 216
  • Figure 36: Properties of Asahi Kasei cellulose nanofiber nonwoven fabric.................................................. 217
  • Figure 37: CNF nonwoven fabric................................................................................................................... 218
  • Figure 38. Graphene anti-smog mask........................................................................................................... 220
  • Figure 39: CNF gel........................................................................................................................................ 227
  • Figure 40: Block nanocellulose material....................................................................................................... 228
  • Figure 41: CNF products developed by Hokuetsu........................................................................................ 228
  • Figure 42: CNF wet powder........................................................................................................................... 235
  • Figure 43: CNF transparent film.................................................................................................................... 236
  • Figure 44: Transparent CNF sheets.............................................................................................................. 236
  • Figure 45. CNF clear sheets.......................................................................................................................... 239
  • Figure 46. ReSpimask® mask....................................................................................................................... 249
  • Figure 47. Nanocellulose mask filter............................................................................................................. 250
  • Figure 48. Guardian G-Volt facemask........................................................................................................... 252
  • Figure 49. Nanofiber filter mask.................................................................................................................... 253
  • Figure 50. Schematic of nanocarriers........................................................................................................... 272
  • Figure 51. Schematic of different nanoparticles used for intranasal vaccination......................................... 273
  • Figure 52. Coronavirus disinfection chamber................................................................................................ 314

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Nanotechnology and nanomaterials solutions to mitigage COVID-19
Nanotechnology and nanomaterials solutions to mitigage COVID-19
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Nanotechnology and nanomaterials solutions to mitigage COVID-19
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Nanotechnology and nanomaterials solutions for COVID-19
Nanotechnology and nanomaterials solutions for COVID-19
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